• ERT and Bioclinica are now Clario. Find out more about our new name, and why we have come together.

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Overview

Clinical trial sponsors look to Clario for the unmatched expertise, scientific insight, and proven centralized imaging services necessary to make timely, critical go/no-go decisions and generate pivotal efficacy or safety information required for successful regulatory submission.

Therapeutic areas

Our team includes physicians and scientists whose expertise spans general medicine therapies.

Click on a therapy below to learn more:

Gastroenterology

Enhance all aspects of your gastroenterology studies with Clario’s broad capabilities and deep scientific expertise in gastroenterology (GI) imaging. From our earliest work in Inflammatory Bowel Disease (IBD), we have expanded into trials focusing on Erosive Esophagitis (EE), Familial Adenomatous Polyposis (FAP), Eosinophilic Esophagitis (EoE), and Fistulizing Crohn’s Disease. Our team of therapeutic experts, including board-certified readers and gastroenterologists, span the globe and have extensive experience with Phase I – IV studies across multiple indications.

We’ve supported 60+ Ulcerative Colitis and 30+ Crohn’s Disease studies and additional indications, including (but not limited to):

  • Bowel prep
  • Celiac Disease
  • Constipation
  • Eosinophilic Esophagitis
  • EGID
  • Eosinophilic Gastroenteritis (EGE)
  • GERD (Gastroesophageal Reflux Disease)
  • Helicobacter Pylori Infection
  • Irritable Bowel Disease (IBD)
  • Perianal Fistula
  • Pouchitis

Our experience covers the complete range of imaging modalities for gastroenterology research, including:

  • Capsule Endoscopy
  • CT Enterography
  • Intestinal Ultrasound (IUS)
  • Magnetic Resonance (MR)
  • MR Enterography
  • Video Endoscopy/Colonoscopy

Hepatology

Leverage Clario’s therapeutic expertise and our best-in-class image analysis and systems for comprehensive Non-Alcoholic Fatty Liver Disease (NAFLD)/Non-Alcoholic Steatohepatitis (NASH) clinical trial management and study support. We perform independent central review of non-invasive magnetic resonance imaging (MRI) techniques in clinical trials to expedite the assessment of disease severity and provide you with more accurate monitoring of therapeutic response.

Supported indications:

  • Beta Thalassemia
  • Biliary Cholangitis
  • Cirrhosis
  • Fatty depot analysis (SAT/VAT)
  • Hepatic Fibrosis
  • Hepatomegaly
  • Primary Sclerosing Cholangitis
  • Nonalcoholic Fatty Liver Disease (NAFLD)
  • Nonalcoholic Steatohepatitis (NASH)
  • Splenomegaly
  • And more

Supported modalities:

  • 2D Magnetic Resonance Elastography (MRE)
  • 3D Magnetic Resonance Elastography (MRE)
  • Biopsy/Histology
  • Computed Tomography (CT)
  • Magnetic Resonance (MR)
  • Ultrasound (US) – CAP and VCTE

Autoimmune Disease & Inflammatory Arthritis

Clario supports imaging endpoints in a wide range of autoimmune diseases affecting multiple body systems including joints, muscles, lungs, skin, and others. There are many challenges, as imaging methods are diverse, and endpoints include a variety of semiquantitative and quantitative assessments.

Among inflammatory arthritis conditions, Clario’s experts, KOL partners, and advisors provide central reading services for all imaging endpoints in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), and Spondyloarthritis (SpA). Using modified Sharp scoring radiographs to assess joint damage, Clario has helped achieve regulatory approval for the majority of therapies currently on the market for RA and PsA. We also support MRI endpoints for both the peripheral (RAMRIS, PsAMRIS, HEMRIS) and axial skeleton (SPARCC, Berlin, Can-Den).

Supported indications:

  • Atopic Dermatitis
  • Ankylosing Spondylitis
  • Dermatomyositis
  • Gout
  • Idiopathic Inflammatory Myopathy
  • Inclusion Body Myositis
  • Juvenile Idiopathic Arthritis
  • Psoriasis
  • Psoriatic Arthritis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren’s Syndrome
  • Spondyloarthritis
  • Systemic Sclerosis
  • Systemic Lupus Erythematosus
  • Thyroid Eye Disease

Supported modalities:

  • Magnetic Resonance Imaging (MRI)
  • Medical Photography
  • Positron Emission Tomography (PET)
  • Ultrasound (US)
  • X-ray

Metabolic

Clario’s scientific experts understand the complexities of metabolic and endocrine studies.  We’ve supported the design, image collection and analysis for more than 60 indications.  Our comprehensive knowledge of specialized imaging for diabetes and obesity supports sponsors bringing new treatments to market.

Supported indications:

  • Diabetes Type 1
  • Diabetes Type 2
  • Endometriosis
  • Fabry Disease
  • Gaucher Disease
  • Glycogen Storage Disease
  • Growth Hormone Deficiency
  • Hormone Replacement Therapy
  • Hormone Deficiency Syndromes
  • Idiopathic Short Stature
  • Morquio Syndrome
  • Niemann Pick Disease
  • Obesity
  • Pyruvate Kinase Deficiency
  • Sanfilippo Syndrome
  • And more

Supported modalities:

  • Computed Tomography (CT)
  • Dual Energy X-ray Absorptiometry (DXA)
  • Magnetic Resonance (MR)
  • Ultrasound (US)

Musculoskeletal (MSK)

Build Clario’s MSK expertise into your next clinical trial. Clario supports the latest developments in imaging endpoints and offers a deep background in Osteoporosis, Sarcopenia, Lumbar Disc Disease and more. Our imaging scientists, technologists, and dedicated MSK project teams have delivered quality service and independent image reviews supporting hundreds of early and late-phase clinical trials. We are the centralized imaging services provider for every approved osteoporosis therapy available today.

  • 700+ MSK studies
  • 40+ indications
  • 17,000+ sites supported

Supported indications:

  • Achondroplasia
  • Arthroplasty
  • Bone Graft Healing/Treatment
  • Chronic low back pain
  • Degenerative Disc Disease
  • Duchenne Muscular Dystrophy
  • Facioscapulohumeral Muscular Dystrophy
  • Fibrodysplasia Ossificans Progressiva
  • Fracture Healing
  • Glucocorticoid Induced Osteoporosis
  • Limb Girdle Muscular Dystrophy
  • Multiple Osteochondromas
  • Osteoarthritis
  • Osteogenesis Imperfecta
  • Osteoporosis
  • Sarcopenia
  • Spinal disc replacement
  • Spinal fusion

Our experience covers the complete range of imaging modalities for MSK research, including:

  • Bone Scintigraphy
  • Computed Tomography (CT)
  • Dual-Energy X-ray Absorptiometry (DXA)
  • High-Resolution Computed Tomography (HRCT)
  • Magnetic Resonance (MR)
  • Quantitative CT
  • Ultrasound (US)
  • X-ray

Osteoarthritis

Leverage our therapeutic expertise, regulatory leadership and global operations to design and expedite your Osteoarthritis trial, from protocol development to regulatory submission. We have more than 30 years of imaging experience supporting 70+ clinical trials in Osteoarthritis.

Scoring mechanisms/criteria:

Efficacy:
  • Bone Marrow Lesion (BML) volume
  • Cartilage thickness
  • Cartilage volume
  • Cartilage composition (i.e. T2 maps)
  • Whole-Organ (WORMS)
  • MRI Osteoarthritis (MOAKS)
  • MRI Observation of Cartilage Repair (MOCART)
  • Radiographic joint space width (JSW)
  • Radiographic knee malalignment
  • Synovitis/Effusion volume
Eligibility:
  • Kellgren-Lawrence Grading
  • OARSI Scoring

Primary imaging modalities:

  • Computed Tomography (CT)
  • Dynamic Contrast Enhanced MRI (DCE-MRI)
  • Magnetic Resonance (MR)
  • X-ray

Rare Disease

Clario’s scientific and medical experts can help you navigate the complexities of imaging endpoints required for your rare disease studies.  Clario provides sponsors with comprehensive clinical trial support – from the start of your trial (protocol design and imaging charter development) to internal/external presentations, all the way through regulatory submission.

Supported indications:

  • Achondroplasia
  • Androgen Deficiency
  • Beta Thalassaemia
  • Fabry Disease
  • Fibrodysplasia Ossificans Progressiva (FOP)
  • Gaucher’s Disease
  • Hemophilia
  • Muscular Dystrophies
  • Neimann Pick Disease
  • Pompe Disease
  • Prader-Willi Syndrome
  • Pyruvate Kinase Deficiency (PKD and ADPKD)
  • Sanfilippo Syndrome Type A
  • Sickle Cell Anemia

Supported modalities:

  • Computed Tomography (CT)
  • Dual-Energy X-ray Absorptiometry (DXA)
  • Magnetic Resonance (MR)
  • Ultrasound (US)
  • X-ray

Respiratory

Rely on Clario’s extensive experience providing clinical imaging and advanced data analysis in primary pulmonary diseases, including obstructive, infectious and Interstitial Lung Disease (ILD).

Our deep expertise ranges from nasal polyp imaging to characterization of lung parenchymal changes and densitometric evaluation to assess the progression of emphysema and airway wall thickening in COPD with CT.

Magnetic Resonance Imaging (MRI), Endobronchial Ultrasound (EBUS), chest Computed Tomography (CT) and Positron Emission Tomography (PET) are among the techniques used in pulmonary imaging of asthma patients to assess both structure and function. In addition, we use tracer-based approaches for ventilation imaging and vascularization imaging.

Supported indications:

  • Alpha-1 Antitrypsin (A1AT) Deficiency
  • Aspergillosis
  • Asthma
  • Bronchitis
  • Bronchiolitis Obliterans Syndrome
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Chronic Rhinosinusitis (CRS) with or without Nasal Polyps
  • Emphysema
  • Fibrotic Hypersensitivity Pneumonitis (FHP)
  • Fungal Rhinosinusitis
  • Idiopathic Pulmonary Fibrosis (IPF)
  • Interstitial Lung Disease (ILD)
  • Pneumonia
  • Pulmonary Fibrosis
  • Sarcoidosis
  • Tuberculosis

Supported modalities:

  • Computed Tomography (CT)
  • Endobronchial Ultrasound (EBUS)
  • Magnetic Resonance Imaging (MRI) 
  • Positron Emission Tomography (PET)

Women’s Health

Clario has a long history with women’s health starting with Osteoporosis. We’ve supported more than 60 studies across a broad range of women’s health indications, including Uterine Fibroids, Endometriosis, Deep Infiltrating Endometriosis (DIE), Hormone Replacement Therapies (HRT), breast density, menopause symptoms and contraception.

Supported indications:

  • Adenomyosis
  • Breast Density
  • Contraception
  • Endometriosis
  • In Vitro Fertilization (IVF)
  • Uterine Fibroids
  • Vulvovaginal Atrophy
  • Polycystic Ovary Syndrome (PCOS)

Supported modalities:

  • Computed Tomography (CT)
  • Dual-Energy X-ray Absorptiometry (DXA)
  • Magnetic Resonance (MR)
  • Mammography
  • Ultrasound (US)

Our expertise also supports studies in the following therapeutic areas:

Endocrinology

Otolaryngology

Medical Devices

Pediatric studies

Meet the team

Clario’s Medical Imaging team has delivered quality service and independent image reviews to support hundreds of clinical trials.

Marcela Vieira headshot

Marcela Vieira Fleury Curado, MD

Medical Director, Gastroenterology

Mark Tendowski headshot

Mark Tengowski, DVM, MS, PhD

Director, Medical & Scientific Affairs

Thomas Fuerst headshot

Thomas Fuerst, PhD

Chief Science Officer

Kenneth Gaither headshot

Kenneth W. Gaither, PhD

VP, Medical Imaging

Souhil Ziam headshot

Souhil Zaim, MD

VP, Medical & Scientific Affairs

Klaus Engelke headshot

Klaus Engelke, PhD

Director of Special Imaging Techniques

Ole Vaeterlein headshot

Ole Vaeterlein, MD

Director, Medical & Scientific Affairs

Contact us to find out how we can support your trial’s medical imaging needs.