DLCO assessment

Diffusing capacity of the lungs for carbon monoxide (DLCO) provides valuable insights into lung disease severity and progression. In clinical trials, DLCO assessment can also help identify drug-induced changes in pulmonary function and help establish the safety profiles of respiratory and non-respiratory therapies.

DLCO, also known as transfer factor for carbon monoxide (TLCO), measures the ability of the lungs to transfer gas from ambient air to circulating red blood cells. This endpoint is assessed through the uptake of carbon monoxide (CO), typically during a 10 second breath-hold of a dilute CO gas mixture. Carbon monoxide is used as a surrogate marker for oxygen as it has a higher affinity for hemoglobin (up to 250X) and its uptake is less impacted by bodily oxygen utilization.

Identification of normal or aberrant DLCO is an important component in the evaluation of various respiratory diseases: 

  • Chronic Obstructive Pulmonary Disease (COPD)
  • Cystic Fibrosis (CF)
  • Asthma
  • Interstitial Lung Disease (ILD)
  • Pulmonary vascular disease Neuromuscular disorders

DLCO trials

ndd® EasyOne Pro

Custom software and data transfer
Expert overread
Centralized data hub
Technician training

ndd® EasyOne Pro

Standardized DLCO device solution

Clario offers standardized, centralized DLCO analysis with the ndd® EasyOne Pro, a high-quality, easy-to-use, lightweight device capable of providing DLCO results in three minutes via single breath diffusion.  The EasyOne Pro is pre-calibrated and requires no warm-up time, leveraging ndd’s proprietary technologies.

Complete, high-resolution digital DLCO and spirometry curves can be easily uploaded directly into Clario’s  EXPERT® database.  Clario over-reads data for consistency and plausibility, alerting the sponsor to potential deviations or sites in need of retraining, ultimately helping sponsors generate the best-possible data.

Solution benefits:

  • Minimizes device, site and gas variability
  • Improved data resolutions and more accurate readings
  • Consistent data labeling
  • Customized workflow captures only timepoints and PPIs dictated by protocol
  • Centralization can reduce variability by up to 50%
  • All gas tanks, regulators and carts are included and sourced from vetted suppliers

Learn more about the ndd EasyOne Pro system

Non-standard, paper-based solution

While losing the benefit of standardized equipment, sponsors interested in using existing equipment at specialized sites can utilize Clario Link, our flexible paper-based solution. A combination of existing site equipment and Clario-provided rental equipment can be used, and digitized paper readings from all sites are uploaded to the Clario EXPERT® portal for centralized review and data reconciliation.

Solution benefits:

  • Low cost
  • Rent devices only when needed
  • Compatible with most existing DLCO capture devices
  • Same great training, review, analysis and reporting
Expert overread
Centralized data hub
Technician training

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