DCT spirometry

Clario provides industry-leading decentralized trial (DCT) spirometry solutions for hybrid and fully remote respiratory studies. These solutions allow at-home testing without compromising functionality, enabling full flow volume loops and helping sponsors generate more robust data to strengthen regulatory submissions.​

Spirometry is assessed for a wide range of indications where it is used as a biomarker for treatment effect, disease progression or lung safety:  ​

  • Asthma​
  • Chronic Obstructive Pulmonary Disease (COPD)​
  • Cystic Fibrosis (CF)​
  • Idiopathic Pulmonary Fibrosis (IPF)​
  • Interstitial Lung Disease (ILD)​
  • Neuromuscular disorders​
  • Non-respiratory indications where the medication is delivered through the lungs or that has a known pulmonary safety signal​

DCT trials


Compact home spirometry solution​

Clario offers DCT convenience without compromise through the iSpiro home spirometry solution. Capable of capturing full, high-resolution inhalation and exhalation data points, the advanced spirometry sensor pairs with the supplied mobile device and iSpiro app to enable pulmonary function testing at home or on-the-go.​

ATS/ERS guidelines have identified coaching as a critical factor in achieving reliable spirometry data. With the iSpiro system, sponsors can leverage real-time remote video coaching, connecting patient and clinician for optimal data quality.

Solution features and benefits:​

  • Captures FEV1, FVC, PEF, FEF25-75, VC, IC, ERV and other metrics​
  • Instant test feedback and notifications bolster patient compliance​
  • Automatic, wireless data transfer to portal​
  • Centralized services can reduce variability by up to 50%​

Real-time remote video coaching


Watch a demo on how the remote coaching solution works

Clario SpiroSphere

Custom software and data transfer
Expert overread
Centralized data hub
Technician training


Hybrid home-nursing solution​

Clario’s proprietary SpiroSphere device was designed for use both on-site and away from the clinic when administered by a healthcare professional. Equipped with a convenient carrying case, the portable and wireless SpiroSphere system can be used to capture complete, standard spirometry metrics in the home setting by a trained nurse or clinician.​

Designed with extensive trial site feedback, the SpiroSphere device is pre-calibrated and leverages single-use, disposable pneumotach tubes to optimize patient safety. Full, high-resolution digital spirometry curves can be effortlessly uploaded to Clario’s EXPERT® platform directly from the SpiroSphere device. 

Solution benefits:​

  • Captures FEV1, FVC, PEF, FEF25-75, VC, IC, ERV and other metrics​
  • Verification of full inflation as recommended by 2019 standards​
  • Rapid setup and automation of clinic-based elements to make at-home testing easier​
  • Reduced cross-contamination risk for patients than site-based systems, yet same focus on quality​
  • Centralization can reduce variability by up to 50%​

Talk to a specialist

Our team of experts is available to address questions you may have about our integrated respiratory solutions. Submit your contact information and we’ll be in touch shortly.