AAN Annual Meeting 2024
The AAN Annual Meeting is the largest gathering of neurologists and neuroscience professionals and is available to attend in person or online. It provides the latest in scientific discoveries and is a great networking event. The programme includes plenary sessions on ‘hot topics’, clinical issues and clinical trials. Its HeadTalk, Innovation and Research hubs, among others, offer creative learning opportunities. The poster hall provides 11 poster sessions throughout the week, where Clario’s Laura Khurana, Principal Scientific Advisor, eCOA Science will present her poster on “The Impact of Trial Design on Diary Compliance in Clinical Trials for Acute and Preventative Migraine Treatments”, on April 16th.
Session information:
Title: The Impact of Trial Design on Diary Compliance in Clinical Trials for Acute and Preventive Migraine Treatments
Date: Tuesday, April 16, 2024
Time: 11:45 a.m. – 12:45 p.m.
Presenting during P7: Headache: Therapeutics 2
Abstract:
Given the differences in treatment goals for acute versus preventive migraine drugs, different electronic patient-reported outcome (ePRO) diary designs are used to capture migraine data. Daily diary compliance is critical for data quality, and there is broad use of episodic diary designs, which ask participants to report each migraine in real time, and daily diary designs that ask participants once per day to report migraine occurrence. Importantly, different designs may impact compliance and ultimately data quality and trial success. The research used ePRO metadata from 17 trials with a mix of episodic and/or daily diaries (n=586,725) and included 6 acute migraine trials and 11 preventive migraine trials. Compliance was calculated for daily diaries only (n=501,112) based on whether there was a diary completed as expected that day. The research found that daily diary compliance in acute migraine trials is lower than in preventive trials and deserves further investigation. Trials with “daily + episodic” designs had lower compliance for daily diaries, which may reflect the increased participant burden associated with the added episodic diary on migraine days.
Presenter
Laura Khurana, MPH
Principal Scientific Advisor at Clario
Ms. Khurana has over 18 years of experience working in public health and clinical research. As a Principal Scientific Advisor at Clario, she is responsible for providing scientific guidance on trial design and strategy, outcomes services and data analysis. Prior to Clario, she worked as a Senior Research Associate at Quintiles and as a Senior Site Management Associate at Outcome Sciences, Inc., where she was responsible for hiring and training the site management team for their office in Geneva, Switzerland. Ms. Khurana earned her B.A. from the University of Georgia and her M.P.H. from Boston University School of Public Health. At BUSPH she helped to design the curriculum for a new master’s level course focused on mHealth, “Using Mobile Technology to Improve Health Outcomes.”