ISCTM 22nd Annual Scientific Meeting
The ISCTM Annual Scientific Meeting is a premier conference organized by the International Society for CNS Clinical Trials and Methodology. It focuses on advancing the field of medical and pharmaceutical research, particularly in the area of central nervous system (CNS) clinical trials.
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Poster session information:
Date: Wednesday, February 4, 2026
Time: 5:45 pm – 7:30 pm ET
Poster Session: From Paper to Precision: Improved MADRS Scoring Accuracy with eCOA Implementation
Abstract:
This study investigates whether using electronic clinical outcome assessments (eCOA) can reduce scoring errors in the Montgomery–Åsberg Depression Rating Scale (MADRS) compared to traditional paper-based methods. In clinical trials for depressive disorders, data variability and rater errors often compromise the reliability of results, with paper-based assessments being particularly prone to mistakes due to manual calculations and transcription. The eCOA platform, by contrast, offers automated scoring, real-time data validation, and built-in consistency checks, which help standardize the assessment process and minimize errors. The researchers analyzed MADRS assessments from two large clinical trials – one using paper and the other eCOA – and found that scoring discrepancies were dramatically lower with eCOA. The findings highlight the clinical and operational benefits of eCOA, such as improved data quality, reduced administrative burden, and greater reliability in psychiatric clinical trials, despite potential methodological differences between the studies.
Presenters
- Stacey Rumerman, Psy.D. – Vice President, Clinical Science at Clario
- Chris Brady, Psy.D. – Vice President, Clinical Solutions at Clario
- Selam Negash, M.Sc, Ph.D. – Senior Director, Study Insight Analytics at Clario
- Igal Seagal, M.Sc. – Senior Data Scientist at Clario
- Mark Opler, Ph.D. – Chief Research Officer, eCOA Neuroscience at Clario
Meet with us at ISCTM 2026
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