Date: Tuesday, September 12, 2023
Time: 12:30 – 14:00 CET
Poster area – PS-15
Poster session – 441
The FIVC should be used as an acceptable substitute for the FVC when evaluating the FVC in neuromuscular disease; experience in a clinical trial for adult myotonic dystrophy
Join us for this poster session to discuss the results and conclusions from an evaluation of forced spirometry measurements in a clinical trial of patients with adult myotonic dystrophy. The 2019 ATS/ERS spirometry standards were employed, including the measurement of the FIVC upon completion of the forced exhalation. We will present data on how often the FIVC was too small to allow evaluation of full inflation and how often the FIVC showed the forced exhalation was started too early. No data on study outcomes will be presented.
Clario Authors: Kevin McCarthy, Phil Lake, Dawn Patterson, Marc Aurel-Baumle, José Ramos
Director, Respiratory Science at Clario
Kevin McCarthy has been working in the field of lung function testing since 1973. He was the manager of the Pulmonary Function Laboratories at the Cleveland Clinic Health System for nearly 40 years, retiring in 2016. Kevin’s research experience includes managing the pulmonary function quality control in two NIH-funded registries: patient with severe A1AT deficiency and LAM Registry and was the site manager at Cleveland Clinic for the NETT study.
Kevin has published extensively on the topic of pulmonary function testing. He is a current member of the ATS PFT Committee and the ATS/ERS Task Force to update the standards for Lung Volume testing. He was a member of the ATS/ERS Task Force that updated the standards for Spirometry in 2019. Kevin is also a member of the faculty that presents the annual MGC Diagnostics Cardiorespiratory Diagnostics Seminar which has been providing excellent pulmonary function education for over 25 years.
Kevin has always been passionate about the quality of pulmonary function measurements. This passion has now moved to the clinical trial world where data quality is critical if these measurements are to accurately answer the questions we are asking. He is now the Director of Respiratory Science at Clario for the US West Coast and Australia.
Relationships between same day FVC and FIVC from forced spirometry and IVC from DLCO; findings in an IPF clinical trial
Join this poster session discussion to hear about our evaluation of 340 same day measurements of forced spirometry and DLCO from 153 patients in an ongoing clinical trial for IPF. We will present the results on the relationship of FIVC and FVC along with the relationship between IVC in DLCO and FVC and FIVC.
Clario Authors: José Ramos, Phil Lake, Dawn Patterson, Marc Aurel-Baumle, Kevin McCarthy
Director, Respiratory Solutions/Business Development at Clario
José is a Director of Respiratory Solutions and a leader in the clinical trials industry and has been a student of lung function testing since 1995. He spent most of his career at Cleveland Clinic as a respiratory therapist in the Pulmonary Function Laboratory, as a Technologist, Supervisor, Manager, and then Director before joining Clario. José assisted in the expansion of Pulmonary Function Labs at Cleveland Clinic taking it from 10 rooms at the main facility to over 38 rooms at 23 sites in Greater Cleveland and then expanding that network to satellites in Florida, Abu Dhabi, and London.
Jose has a passion for teaching and enjoys sharing his knowledge of lung function testing. He now brings that passion and knowledge of pulmonary function testing to focus on improving data quality for all clinical trials with respiratory measurements. “I am a strong believer that the proof is in the pudding. The rigorous requirements of clinical trials demand that lung function data be of the highest quality from the beginning to the end”.
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