OVERVIEW
Run smoother trials with less risk
Clinical trials are complex enough – don’t let adjudication slow you down. Clario delivers fast, independent adjudication services that meets the highest compliance standards and keeps your study moving forward.
- Extensive adjudication experience across all trial phases and therapeutic areas
- 15,000+ active users across sites, sponsors, and CROs in 61 countries
- Dedicated adjudication experts
- Large, global network of KOLs
Adjudication services to keep your trials on track
Accelerate your timelines
Real-time case routing and automated workflows keep reviews moving – no bottlenecks.
Deliver compliant and submission-ready data
Every decision is fully documented and aligned with 21 CFR Part 11, GDPR, and ICH standards – no extra burden on your team.
Reduce variability, boost confidence
Expert reviewers use standard definitions and strict controls, to enable consistent, defensible outcomes.
Streamline your oversight
Confidently hand off charter development, training, reviewer coordination, and consensus-building with full-service support.
Our solutions solve your problems
Your concern
How we deliver
Your concerns and how we deliver
“We need to stay on timeline.”
- Automation, real-time tracking, and quick turnarounds
“Our trial’s under regulatory scrutiny.”
- Fully compliant workflows and audit-ready records
“Our team is stretched thin.”
- End-to-end support from start to submission
“We don’t want bias to tank our results.”
- Independent, blinded committees without sponsor influence
“We need global scale.”
- A worldwide pool of adjudicators across all major therapeutic areas
Technology designed to deliver for you
- Secure, web-based access allows you to review cases anytime, anywhere
- Auto-routed cases with built-in discordance detection to prevent delays
- AI-driven redaction protects patient confidentiality
- Built-in compliance with 21 CFR Part 11 and GDPR
Expertise that drives accuracy
- Handpicked adjudicators with therapeutic area and event type specialization
- Experienced clinical nurse reviewers drive accuracy and reduce bias
- Scalable teams ready to support trials of any size
Support that lightens your load
- User training for sites, sponsors and committees – faster ramp up, fewer errors
- Clean, structured data – ready for analysis and submission
- Project specific dashboards – full transparency on case status in real time
Comprehensive adjudication for every endpoint
No matter your therapeutic area, Clario delivers standardized, reproducible adjudication for the events regulators care about most, including (but not limited to):
Interstitial Lung Disease (ILD)
Diagnoses, exacerbations, and disease progression -critical in oncology and autoimmune trials.
Major Adverse Cardiovascular Events (MACE)
Includes endpoints such as myocardial infarction, stroke, and cardiovascular death.
Medical Device Events
Cardiovascular implantable devices, transcatheter heart valves, and transcatheter aortic valve replacement (TAVR).
Oncology Endpoint Adjudication
Independent assessment of disease progression, objective response rate (ORR), aligned with FDA/EMA guidance.
Infectious Disease Events
Evaluation of clinical cure, microbiologic eradication, or infection recurrence.
Renal and Hepatic Events
Adjudication of acute kidney injury (AKI), chronic kidney disease (CKD) progression, or hepatic failure.
Thromboembolic Events
Includes deep vein thrombosis (DVT), pulmonary embolism (PE), and other venous or arterial events.
Bleeding Events
Categorization by severity using standard scales (e.g., BARC, GUSTO, TIMI).
Neurology Events
Adjudication of seizures, strokes, and other CNS-related endpoints.
Respiratory Events
Assessment of acute exacerbations, hospitalizations, or respiratory-related deaths.
Death Classification
Independent determination of cause of death – cardiac, non-cardiac, unknown, etc.
Custom Endpoints
Tailored adjudication based on protocol-specific definitions and study requirements.
Adjudication that adds value – not delays
Clario protects your data, your timeline, and your submission. We simplify complex trials, deliver reliable outcomes, and turn regulatory risk into confidence.
Ready to simplify adjudication and stay on schedule?
Talk to us today and see how Clario keeps your trial moving – with confidence, clarity, and compliance.