OVERVIEW
Solving the complexities of pain research
At Clario, we combine validated eCOA strategies, advanced imaging biomarkers, and proven placebo mitigation methods to deliver reliable, high-quality data. Our integrated solutions don’t just support pain trials – they help elevate them, so sponsors can make confident evidence-based decisions.
SOLUTIONS AND EXPERTISE
Comprehensive solutions for pain trials
Improve data accuracy with ePRO and eDiaries
Patient-reported outcomes (PROs) and daily diaries are essential for capturing treatment effects in pain studies, yet traditional methods can lead to incomplete or inaccurate data. Our eCOA solutions maintain data integrity, improve compliance, and streamline reporting.
- eDiaries with timestamped, validated entries to meet FDA ALCOA standards
- Automated reminders to enhance patient adherence
- Real-time data monitoring for improved trial efficiency
Select the right pain scales and mitigate placebo response
Pain manifests in diverse ways, making endpoint selection complex. Our eCOA scientists provide expert guidance in choosing validated pain scales, while our proven placebo response mitigation strategies help improve signal detection and reduce variability.
- Expert recommendations on validated pain assessment tools
- Investigator training to minimize placebo response impact
- Scientifically backed mitigation strategies that enhance trial success
Enhance trial design with advanced imaging and biomarkers
Pain perception is influenced by complex neurological pathways. Our medical imaging experts leverage MRI, PET, and other advanced imaging modalities to assess brain function and biomarkers, providing deeper insights into treatment effects.
- Brain imaging to identify pain-related biomarkers
- Advanced data analysis to support regulatory decision-making
- Reliable imaging endpoints for stronger clinical evidence
Protect trial integrity with expert clinical adjudication
Pain trials often require independent evaluation of safety events and treatment efficacy. Our Clinical Event Committee (CEC) provides expert adjudication to provide standardized, objective and reliable assessments.
- Blinded, independent expert review of clinical outcome and safety events
- Standardized classification for regulatory compliance
- Comprehensive data integrity for trial success
Partner with Clario for reliable, actionable data
Let’s work together to advance pain research with confidence
With extensive experience in pain trials, we provide the expertise, technology, and regulatory support needed to overcome common challenges. From optimizing eCOA strategies to leveraging advanced imaging and safety monitoring, we help support your trial to deliver meaningful, high-quality results.